[猴腺病毒SA7 DNA的转化活性与致癌性]
[Transforming activity and the oncogenicity of simian adenovirus SA7 DNA].
作者信息
Ponomareva T I, Chaplygina N M, Naroditskiĭ B S, Grodnitskaia N A, Dreĭzin R S
出版信息
Biull Eksp Biol Med. 1979 Dec;88(12):699-700.
The transforming and oncogenous activity of uncleaved DNA of simian adenovirus SA7 (AdSA7) and the products of its restriction by endonucleases R. Bam HI and R. SalI was studied. It was shown that uncleaved virus DNA transformed the rat kidney cells and rat embryo fibroblasts and induced tumors in newborn hamsters. AdSA7 DNA, hydrolysed by R. Bam HI, posessed the transforming activity. The mixture of DNA fragments, obtained after hydrolysis by R. SalI was oncogenous in hamsters.
研究了猿猴腺病毒SA7（AdSA7）未切割的DNA及其经限制性内切酶R. Bam HI和R. SalI切割后的产物的转化和致癌活性。结果表明，未切割的病毒DNA可转化大鼠肾细胞和大鼠胚胎成纤维细胞，并在新生仓鼠中诱发肿瘤。经R. Bam HI水解的AdSA7 DNA具有转化活性。经R. SalI水解后获得的DNA片段混合物在仓鼠中具有致癌性。
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