Soboll H, Fenyves A, Strupp L
Arch Virol. 1981;69(3-4):189-96. doi: 10.1007/BF01317334.
Simian adenovirus SA7 heated for 30 minutes at 70 degrees C retained part of its ability to induce tumors in newborn hamsters. Tumors were also induced by DNA extracted from the heated virus. However, neither residual replicating, i.e. cytopathogenic, nor transforming and T-antigen-inducing activities could be detected in vitro in CV-1 and hamster embryo cells inoculated with the heated virus. The results are discussed in terms of a possible release of viral nucleic acid at the high temperature. They also show that current tests for effective virus inactivation based exclusively on the recognition of replicating virus should be reevaluated.
猿猴腺病毒SA7在70摄氏度下加热30分钟后，仍保留了部分在新生仓鼠体内诱发肿瘤的能力。从加热后的病毒中提取的DNA也能诱发肿瘤。然而，在用加热后的病毒接种的CV-1细胞和仓鼠胚胎细胞中，在体外均未检测到残留的复制能力（即细胞致病能力）、转化能力以及诱导T抗原的能力。根据高温下病毒核酸可能释放的情况对结果进行了讨论。这些结果还表明，当前仅基于识别复制病毒来进行有效病毒灭活的测试应该重新评估。
