Potebnia G P, Struk V I, Naroditskiĭ B S, Ponomarev T I, Tikhonenko T I
Eksp Onkol. 1986;8(2):26-9.
Benz(a)pyrene in a concentration of 2.5 micrograms/ml produced a 3.3-fold increase in the transforming activity of simian adenovirus S5 in primary cultures of rat kidney cells. Under analogous conditions TPA increased (2.1 times) the transforming activity of DNA of human adenovirus of type I (AdI). PX5 cells (cotransformed by S5 and benz(a)pyrene) induced tumours in 100% of syngeneic and 81% xenogeneic animals. PX4 cells (transformed by S5 only) induced tumours in 60% of syngeneic animals. Cells transformed by DNA AdI and DNA AdI + TPA did not induce tumours in animals.
浓度为2.5微克/毫升的苯并(a)芘使猿猴腺病毒S5在大鼠肾细胞原代培养物中的转化活性提高了3.3倍。在类似条件下，佛波酯使I型人腺病毒（AdI）DNA的转化活性提高了2.1倍。PX5细胞（由S5和苯并(a)芘共转化）在100%的同基因动物和81%的异种动物中诱发肿瘤。PX4细胞（仅由S5转化）在60%的同基因动物中诱发肿瘤。由AdI DNA和AdI DNA + 佛波酯转化的细胞在动物中未诱发肿瘤。
