Veyrat-Durebex C, Gaudreau P, Boghossian S, Alliot J
Laboratoire de Neuroendocrinologie du vieillissement, Université Blaise Pascal, 63177, Aubière, France.
Peptides. 2001 Dec;22(12):2119-26. doi: 10.1016/s0196-9781(01)00560-5.
In aging LOU rats, a decreased protein intake is restored by GH administration. To study the contribution of GHRH to macronutrient selection, hGHRH NH(2) was administered sc. (1 mg/kg B.W./day/14 days) or icv. (4 and 40 pmol/rat) to 11-, 19-, 24- and 28-month-old rats. Sc. administration induced a decreased food and lipid intakes from 24 months of age and a transient stimulation of protein intake in 19-month-old and older low protein eaters (<10% protein/total intake). Icv. administration induced decreased food and lipid intakes in all age groups. These results suggest that GHRH may regulate feeding through pituitary and/or hypothalamic GHRH receptor mechanisms.
在衰老的LOU大鼠中，生长激素（GH）给药可恢复减少的蛋白质摄入量。为研究生长激素释放激素（GHRH）对常量营养素选择的作用，将人GHRH NH₂皮下注射（1毫克/千克体重/天/14天）或脑室内注射（4和40皮摩尔/只大鼠）给11、19、24和28月龄大鼠。皮下注射导致24月龄起食物和脂质摄入量减少，对19月龄及以上低蛋白饮食者（蛋白质摄入量占总摄入量<10%）的蛋白质摄入有短暂刺激作用。脑室内注射导致所有年龄组的食物和脂质摄入量减少。这些结果表明，GHRH可能通过垂体和/或下丘脑GHRH受体机制调节进食。
