外周注射鸡生长激素释放激素可抑制雏鸡的摄食行为。
Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks.
作者信息
Tachibana Tetsuya, Kubo Sachiyo, Khan Md Sakirul Islam, Masuda Keiko, Ukena Kazuyoshi, Wang Yajun
机构信息
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon 791-0212, Ehime, Japan.
出版信息
J Poult Sci. 2016 Jan 25;53(1):29-33. doi: 10.2141/jpsa.0150087.
Growth hormone-releasing hormone (GHRH), a stimulator of growth hormone (GH) secretion, is known to have several physiological roles such as the regulation of feeding behavior in mammals. Recently, we have reported that central injection of chicken GHRH decreased food intake in chicks, however, its peripheral role on feeding behavior has not been clarified. The purpose of the present study was to investigate the effect of peripheral injection of GHRH on feeding behavior in chicks (). Intraperitoneal (IP) injection of GHRH47 (1 nmol), full length form of chicken GHRH significantly decreased food intake in chicks although the injection of GHRH27 and GHRH27-NH, short forms of chicken GHRH had no effect. The IP injection of GHRH47 did not induced any abnormal behavior, suggesting that GHRH47-induced anorexia might not be related to abnormal behavior such as sleeping, hyperactivity and convulsion. The anorexigenic effect of GHRH47 seemed not to be related to GH because IP injection of bovine GH did not affect feeding behavior in chicks. Collectively, these results suggest that peripheral GHRH is related to inhibit feeding behavior in chicks.
生长激素释放激素（GHRH）是生长激素（GH）分泌的刺激物，已知具有多种生理作用，如调节哺乳动物的摄食行为。最近，我们报道了向雏鸡中枢注射鸡GHRH可减少其食物摄入量，然而，其对摄食行为的外周作用尚未阐明。本研究的目的是调查向雏鸡外周注射GHRH对其摄食行为的影响（）。腹腔注射GHRH47（1纳摩尔），即鸡GHRH的全长形式，可显著减少雏鸡的食物摄入量，而注射鸡GHRH的短形式GHRH27和GHRH27-NH则没有效果。腹腔注射GHRH47未诱发任何异常行为，这表明GHRH47诱导的厌食可能与睡眠、多动和惊厥等异常行为无关。GHRH47的厌食作用似乎与GH无关，因为腹腔注射牛GH对雏鸡的摄食行为没有影响。总体而言，这些结果表明外周GHRH与抑制雏鸡的摄食行为有关。
Zotero 插件