Raulin Christian, Greve Baerbel, Hammes Stefan
Laserklinik Karlsruhe, Kaiserstr 104, D-76133 Karlsruhe, Germany.
Arch Dermatol. 2002 Jan;138(1):33-7. doi: 10.1001/archderm.138.1.33.
Pyogenic granuloma is a frequently diagnosed, benign vascular lesion.
To present the use of the combined continuous-wave/pulsed carbon dioxide (CO2) laser as an innovative therapeutic method, to compare it with established methods, and to assess its results.
Prospective observational study between March 1998 and July 2000, comprising 1 treatment session with 6-week and 6-month follow-up examinations and evaluations.
Private or institutional practices as well as ambulatory or hospitalized care.
One hundred patients with pyogenic granuloma selected from a population-based sample.
Treatment with CO2 laser. The laser was first used in continuous mode (power, 15 W) and then in pulsed mode (pulse length, 0.6-0.9 milliseconds; energy fluence, 500 mJ/pulse).
Complete resolution of treated granuloma pyogenicum.
Pyogenic granuloma was removed completely in 1 treatment session in 98 patients without recurrence. In 88 cases there were no visible scars; in 10 cases slight textural changes of the skin were observed. Hypertrophic scars or keloids did not occur. Sixty-three patients were very satisfied with the result of the treatment, 37 were satisfied (ie, 100% patient satisfaction), and none indicated that they were not satisfied. No permanent hypopigmentation, hyperpigmentation, or erythema was observed.
The combined continuous-wave/pulsed CO2 laser is our treatment of choice for pyogenic granuloma because this kind of laser is widely available, produces excellent results with few adverse effects, is easy to use, yields low recurrence rates, and is well tolerated by most patients.
化脓性肉芽肿是一种常被诊断出的良性血管病变。
介绍连续波/脉冲二氧化碳（CO₂）激光联合使用作为一种创新治疗方法，将其与现有方法进行比较，并评估其效果。
1998年3月至2000年7月的前瞻性观察性研究，包括1次治疗疗程以及6周和6个月的随访检查与评估。
私人或机构诊所，以及门诊或住院护理。
从基于人群的样本中选取的100例化脓性肉芽肿患者。
使用CO₂激光治疗。激光首先以连续模式（功率15瓦）使用，然后以脉冲模式（脉冲长度0.6 - 0.9毫秒；能量密度500毫焦/脉冲）使用。
治疗的化脓性肉芽肿完全消退。
98例患者在1次治疗疗程中化脓性肉芽肿被完全清除且无复发。88例未见明显瘢痕；10例观察到皮肤有轻微质地改变。未出现肥厚性瘢痕或瘢痕疙瘩。63例患者对治疗结果非常满意，37例满意（即患者满意度为100%），无人表示不满意。未观察到永久性色素减退、色素沉着或红斑。
连续波/脉冲CO₂激光联合使用是我们治疗化脓性肉芽肿的首选方法，因为这种激光广泛可得，产生的效果极佳且不良反应少，易于使用，复发率低，并且大多数患者耐受性良好。
