吞噬作用与先天免疫
Phagocytosis and innate immunity.
作者信息
Greenberg Steven, Grinstein Sergio
机构信息
Columbia University, Departments of Medicine and Pharmacology/BB914, 630 West 168th Street, New York, NY 10032, USA.
出版信息
Curr Opin Immunol. 2002 Feb;14(1):136-45. doi: 10.1016/s0952-7915(01)00309-0.
Abstract
Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed a fundamental requirement for two co-ordinated cellular processes--cytoskeletal alterations and membrane trafficking--in the phagocytic event. Some elements of this machinery are co-opted by certain pathogens to gain entry into host cells.
摘要
吞噬作用是许多细胞用于摄取微生物病原体、凋亡和坏死细胞尸体的一种进化上保守的过程。最近的研究揭示了吞噬事件中两个协调的细胞过程——细胞骨架改变和膜运输——的基本要求。某些病原体利用这一机制的一些元件进入宿主细胞。
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