Thakur Mony, Singh Mona, Kumar Sandeep, Dwivedi Ved Prakash, Dakal Tikam Chand, Yadav Vinod
Department of Microbiology, Central University of Haryana, Mahendergarh, Haryana 123031, India.
Department of Obstetrics and Gynaecology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
ACS Pharmacol Transl Sci. 2023 Oct 10;6(11):1600-1615. doi: 10.1021/acsptsci.3c00178. eCollection 2023 Nov 10.
In the present era of the COVID-19 pandemic, viral infections remain a major cause of morbidity and mortality worldwide. In this day and age, viral infections are rampant and spreading rapidly. Among the most aggressive viral infections are ebola, AIDS (acquired immunodeficiency syndrome), influenza, and SARS (severe acute respiratory syndrome). Even though there are few treatment options for viral diseases, most of the antiviral therapies are ineffective owing to frequent mutations, the development of more aggressive strains, drug resistance, and possible side effects. Traditionally, herbal remedies have been used by healers, including for dietary and medicinal purposes. Many clinical and scientific studies have demonstrated the therapeutic potential of plant-derived natural compounds. Because of unsafe practices like blood transfusions and organ transplants from infected patients, medical supply contamination. Our antiviral therapies cannot achieve sterile immunity, and we have yet to find a cure for these pernicious infections. Herbs have been shown to improve therapeutic efficacy against a wide variety of viral diseases because of their high concentration of immunomodulatory phytochemicals (both immunoinhibitory and anti-inflammatory). Combined with biotechnology, this folk medicine system can lead to the development of novel antiviral drugs and therapies. In this Review, we will summarize some selected bioactive compounds with probable mechanisms of their antiviral actions, focusing on the immunological axis of these compounds.
在当前新冠疫情时代，病毒感染仍是全球发病和死亡的主要原因。在这个时代，病毒感染猖獗且传播迅速。最具侵袭性的病毒感染包括埃博拉病毒、艾滋病（获得性免疫缺陷综合征）、流感和严重急性呼吸综合征（SARS）。尽管针对病毒疾病的治疗选择很少，但由于病毒频繁突变、更具侵袭性毒株的出现、耐药性以及可能的副作用，大多数抗病毒疗法都无效。传统上，治疗师会使用草药疗法，包括用于饮食和药用目的。许多临床和科学研究已经证明了植物源天然化合物的治疗潜力。由于存在不安全做法，如来自感染患者的输血和器官移植、医疗用品污染。我们的抗病毒疗法无法实现无菌免疫，而且我们尚未找到治愈这些恶性感染的方法。由于草药含有高浓度的免疫调节植物化学物质（包括免疫抑制和抗炎物质），已被证明能提高对多种病毒疾病的治疗效果。结合生物技术，这种民间医学体系能够促成新型抗病毒药物和疗法的开发。在本综述中，我们将总结一些选定的具有抗病毒作用可能机制的生物活性化合物，重点关注这些化合物的免疫轴。
