慢呼吸可提高慢性心力衰竭患者的动脉压力感受器反射敏感性。

Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure.

作者信息

Bernardi Luciano, Porta Cesare, Spicuzza Lucia, Bellwon Jerzy, Spadacini Giammario, Frey Axel W, Yeung Leata Y C, Sanderson John E, Pedretti Roberto, Tramarin Roberto

机构信息

Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy.

出版信息

Circulation. 2002 Jan 15;105(2):143-5. doi: 10.1161/hc0202.103311.

DOI:10.1161/hc0202.103311

PMID:11790690

Abstract

BACKGROUND

It is well established that a depressed baroreflex sensitivity may adversely influence the prognosis in patients with chronic heart failure (CHF) and in those with previous myocardial infarction.

METHODS AND RESULTS

We tested whether a slow breathing rate (6 breaths/min) could modify the baroreflex sensitivity in 81 patients with stable (2 weeks) CHF (age, 58+/-1 years; NYHA classes I [6 patients], II [33], III [27], and IV [15]) and in 21 controls. Slow breathing induced highly significant increases in baroreflex sensitivity, both in controls (from 9.4+/-0.7 to 13.8+/-1.0 ms/mm Hg, P<0.0025) and in CHF patients (from 5.0+/-0.3 to 6.1+/-0.5 ms/mm Hg, P<0.0025), which correlated with the value obtained during spontaneous breathing (r=+0.202, P=0.047). In addition, systolic and diastolic blood pressure decreased in CHF patients (systolic, from 117+/-3 to 110+/-4 mm Hg, P=0.009; diastolic, from 62+/-1 to 59+/-1 mm Hg, P=0.02).

CONCLUSIONS

These data suggest that in patients with CHF, slow breathing, in addition to improving oxygen saturation and exercise tolerance as has been previously shown, may be beneficial by increasing baroreflex sensitivity.

摘要

背景

压力反射敏感性降低会对慢性心力衰竭（CHF）患者及既往有心肌梗死患者的预后产生不利影响，这一点已得到充分证实。

方法与结果

我们对81例病情稳定（2周）的CHF患者（年龄58±1岁；纽约心脏协会心功能分级：I级[6例]、II级[33例]、III级[27例]和IV级[15例]）以及21名对照者进行测试，观察呼吸频率减慢（6次/分钟）是否能改善压力反射敏感性。呼吸频率减慢使对照者（从9.4±0.7至13.8±1.0毫秒/毫米汞柱，P<0.0025）和CHF患者（从5.0±0.3至6.1±0.5毫秒/毫米汞柱，P<0.0025）的压力反射敏感性均显著增加，且与自主呼吸时测得的值相关（r = +0.202，P = 0.047）。此外，CHF患者的收缩压和舒张压均下降（收缩压从117±3降至110±4毫米汞柱，P = 0.009；舒张压从62±1降至59±1毫米汞柱，P = 0.02）。