Lacroix B, Kedinger M, Simon-Assmann P, Haffen K
Gut. 1984 Sep;25(9):925-30. doi: 10.1136/gut.25.9.925.
Human small bowel early organogenesis was studied by scanning electron microscopy and found to be correlated to brush border enzymology. The appearance of the brush border enzymes sucrase, lactase, and aminopeptidase (measured in a purified apical membrane fraction) coincides with the first outgrowth of villi (eight weeks). Alkaline phosphatase was detected at seven weeks. The content of these enzymes furthermore increased up to the 14th week when both sucrase and aminopeptidase activities were comparable with adult values.
通过扫描电子显微镜对人类小肠早期器官发生进行了研究，发现其与刷状缘酶学相关。刷状缘酶蔗糖酶、乳糖酶和氨肽酶（在纯化的顶端膜部分进行测量）的出现与绒毛的首次长出（八周时）同时发生。碱性磷酸酶在七周时被检测到。这些酶的含量在第14周之前进一步增加，此时蔗糖酶和氨肽酶的活性与成人水平相当。
