Nagasawa T
Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan.
Ann N Y Acad Sci. 2001 Dec;947:112-5; discussion 115-6. doi: 10.1111/j.1749-6632.2001.tb03933.x.
Chemokines are a family of small, structurally related molecules that regulate cell trafficking. We isolated a chemokine, stromal cell-derived factor/pre-B cell growth-stimulating factor (SDF-1/PBSF), as a molecule that stimulates the growth of B lymphocyte precursors and then found its multiple physiological functions in development. SDF-1/PBSF is essential for embryonic viability, B lymphopoiesis, bone marrow myelopoiesis, and cardiogenesis. Moreover, a primary physiologic receptor for SDF-1/PBSF is a seven-transmembrane G-protein-coupled receptor, CXCR4, that also functions as a coreceptor for strains of HIV-1. In recent years, we have shown that SDF-1/ PBSF and CXCR4 chemokine ligand receptor system is required for vascularization of the gastrointestinal tract by analyzing mice deficient in these molecules, thus defining a new signaling system for organ vascularization during embryogenesis.
趋化因子是一类结构相关的小分子家族，可调节细胞迁移。我们分离出一种趋化因子，即基质细胞衍生因子/前B细胞生长刺激因子（SDF-1/PBSF），它是一种刺激B淋巴细胞前体生长的分子，随后发现其在发育过程中具有多种生理功能。SDF-1/PBSF对胚胎存活、B淋巴细胞生成、骨髓髓细胞生成和心脏发生至关重要。此外，SDF-1/PBSF的主要生理受体是一种七跨膜G蛋白偶联受体CXCR4，它也是HIV-1毒株的共受体。近年来，我们通过分析缺乏这些分子的小鼠，表明SDF-1/PBSF和CXCR4趋化因子配体受体系统是胃肠道血管形成所必需的，从而确定了胚胎发育过程中器官血管形成的新信号系统。
