Nagasawa T, Tachibana K, Kishimoto T
Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka, 590-02, Japan.
Semin Immunol. 1998 Jun;10(3):179-85. doi: 10.1006/smim.1998.0128.
PBSF/SDF-1 is a CXC chemokine which has unique functions among chemokines. It is essential for viability of the embryo, B lymphopoiesis, bone marrow hematopoiesis and cardiogenesis. A receptor for PBSF/SDF-1 was shown to be CXCR4 that is an entry co-receptor for T cell line-tropic HIV-1. Although murine cells had been thought to have no functional co-receptors, murine CXCR4 allowed entry of HIV-1 into target cells with human CD4. In addition, a small molecule CXCR4 inhibitor that blocks HIV-1 entry was identified.
血小板碱性蛋白/基质细胞衍生因子-1（PBSF/SDF-1）是一种CXC趋化因子，在趋化因子中具有独特功能。它对于胚胎的存活、B淋巴细胞生成、骨髓造血及心脏发生至关重要。PBSF/SDF-1的一种受体被证明是CXCR4，它是嗜T细胞系HIV-1的一种进入共受体。尽管曾认为鼠细胞没有功能性共受体，但鼠CXCR4可使HIV-1借助人CD4进入靶细胞。此外，还鉴定出一种可阻断HIV-1进入的小分子CXCR4抑制剂。
