Pani G, Bedogni B, Colavitti R, Anzevino R, Borrello S, Galeotti T
Institute of General Pathology, Catholic University Medical School, Rome, Italy.
IUBMB Life. 2001 Jul;52(1-2):7-16. doi: 10.1080/15216540252774702.
From a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets. In particular, a major distinction between oxidative events in the cytosolic versus the mitochondrial compartment appears to exist in terms of physiological stimuli, signaling mechanisms and functional consequences. Experimental data supporting this view are reviewed here, and the potential implications of this new perspective in redox signaling are discussed.
从越来越多关于活性氧作为细胞内信号分子作用的证据来看，一种概念开始浮现，即细胞对氧化还原变化的反应是氧化剂产生和/或与分子靶点相遇的细胞内位置的函数。特别是，就生理刺激、信号传导机制和功能后果而言，胞质与线粒体区室中的氧化事件之间似乎存在重大区别。本文回顾了支持这一观点的实验数据，并讨论了这一新观点在氧化还原信号传导中的潜在影响。
