一种通用且温和的丙二酸二乙酯的铜催化芳基化反应。
A general and mild copper-catalyzed arylation of diethyl malonate.
作者信息
Hennessy Edward J, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2002 Jan 24;4(2):269-72. doi: 10.1021/ol017038g.
[reaction: see text] A general method for the synthesis of alpha-aryl malonates is described. The coupling of an aryl iodide and diethyl malonate in the presence of Cs(2)CO(3) and catalytic amounts of copper(I) iodide and 2-phenylphenol affords the alpha-aryl malonate in good to excellent yields. The mild reaction conditions and high levels of functional group compatibility make this an attractive synthetic alternative to previous methods.
[反应：见正文] 描述了一种合成α-芳基丙二酸酯的通用方法。在碳酸铯、催化量的碘化亚铜和2-苯基苯酚存在下，芳基碘化物与丙二酸二乙酯偶联，以良好至优异的产率得到α-芳基丙二酸酯。温和的反应条件和高水平的官能团兼容性使其成为比以前方法更具吸引力的合成选择。
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