一种用于吖啶及相关杂环化合物的铜催化自由基交叉脱氢偶联方法。
A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.
作者信息
Hurst Timothy E, Taylor Richard J K
机构信息
Department of Chemistry University of York Heslington YO10 5DD York UK.
出版信息
European J Org Chem. 2017 Jan 3;2017(1):203-207. doi: 10.1002/ejoc.201601336. Epub 2017 Jan 6.
Abstract
The synthesis of acridanes and related compounds through a Cu-catalysed radical cross-dehydrogenative coupling of simple 2-[2-(arylamino)aryl]malonates is reported. This method can be further streamlined to a one-pot protocol involving the in situ fomation of the 2-[2-(arylamino)aryl]malonate by α-arylation of diethyl malonate with 2-bromodiarylamines under Pd catalysis, followed by Cu-catalysed cyclisation.
摘要
报道了通过简单的2-[2-(芳基氨基)芳基]丙二酸酯的铜催化自由基交叉脱氢偶联反应合成吖啶及其相关化合物。该方法可以进一步简化为一锅法，即在钯催化下，通过丙二酸二乙酯与2-溴二芳基胺的α-芳基化反应原位生成2-[2-(芳基氨基)芳基]丙二酸酯，然后进行铜催化环化反应。
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