Brauer L H, Cramblett M J, Paxton D A, Rose J E
Department of Psychiatry, University of Minnesota, Mayo Mail Code 392, 420 Delaware Street S.E., Minneapolis, MN 55455, USA.
Psychopharmacology (Berl). 2001 Dec;159(1):31-7. doi: 10.1007/s002130100894. Epub 2001 Sep 4.
Studies with laboratory animals and humans suggest that dopamine may play a role in maintaining cigarette smoking behavior via its interactions with nicotine.
This study was designed to replicate and extend previous findings showing that the dopamine D2 antagonist, haloperidol, produces blockade of smoking reward and compensatory increases in smoking.
We studied 20 subjects in a 2x3 within-subjects design, with nicotine-containing or denicotinized cigarettes crossed with oral placebo, haloperidol 1 mg, or haloperidol 2 mg. Subjects attended six sessions during which they received one of the cigarette/drug combinations, and smoked under both controlled and ad libitum conditions. Cigarette and mood ratings and smoking behavior were assessed.
Haloperidol reduced the number of cigarettes smoked and the carbon monoxide boost associated with both types of cigarettes, at doses that did not appear to produce clinically significant behavioral effects.
Dopamine appears to play a role in mediating smoking behavior, but this may occur through a non-nicotine mechanism.
对实验动物和人类的研究表明，多巴胺可能通过与尼古丁的相互作用在维持吸烟行为中发挥作用。
本研究旨在重复并扩展先前的研究结果，即多巴胺D2拮抗剂氟哌啶醇可阻断吸烟奖赏并导致吸烟量代偿性增加。
我们采用2×3被试内设计对20名受试者进行了研究，将含尼古丁香烟或去尼古丁香烟与口服安慰剂、1毫克氟哌啶醇或2毫克氟哌啶醇进行交叉组合。受试者参加六个疗程，在此期间他们接受其中一种香烟/药物组合，并在控制条件和自由条件下吸烟。评估了香烟和情绪评分以及吸烟行为。
在似乎未产生临床显著行为影响的剂量下，氟哌啶醇减少了两种香烟的吸烟量以及与吸烟相关的一氧化碳增加量。
多巴胺似乎在介导吸烟行为中发挥作用，但这可能是通过非尼古丁机制发生的。
