Dragicevic J, Drecun V, Mitrovic D, Jevtovic Dj, Bukilica M, Vucelja O
Bezhanijska Kosa, Medical Centre, Belgrade.
Srp Arh Celok Lek. 2001 May-Jun;129(5-6):135-8.
Sharp's syndrome is a systemic mixed connective tissue disease that is defined with specific ribonucleoprotein antibody (U1RNP). The key diagnostic criterion is positive antinuclear antibodies in stain form. The disease is primarily localized on joints, muscles and skin; however, there are not widely used diagnostic criteria. There are USA, Mexican and Japanese diagnostic criteria. A 18-year-old male who fulfilled Sharp's diagnostic criteria is presented in the paper. In this patient the disease was manifested in pleura and pericardium. We wish to point out the importance of immunologic approach to the aetiology of pleural and pericardial inflammatory effusions in young patients, as well as the therapeutical dilemmas in the treatment of the disease.
夏普综合征是一种系统性混合性结缔组织病，由特定的核糖核蛋白抗体（U1RNP）所定义。关键诊断标准是抗核抗体呈染色阳性形式。该疾病主要累及关节、肌肉和皮肤；然而，目前尚无广泛应用的诊断标准。有美国、墨西哥和日本的诊断标准。本文报道了一名符合夏普诊断标准的18岁男性患者。该患者的疾病表现于胸膜和心包。我们希望指出免疫方法对于年轻患者胸膜和心包炎性积液病因学的重要性，以及该疾病治疗中的治疗困境。
