Richard P, Sabouret P, Vayre F, Desrame J, Ollivier J P
Service de Cardiologie, Hôpital du Val-de-Grâce, Paris.
Ann Cardiol Angeiol (Paris). 1996 Nov;45(9):513-5.
Mixed connective tissue diseases or Sharp's syndrome are inflammatory diseases essentially presenting in the form of joint, muscle and skin manifestations. Pleuropericardial involvement is uncommon and rarely the presenting sign, and tamponade is exceptional. This clinical report concerns a case of pleuropericarditis complicated by tamponade in a 22-year-old man, constituting the presenting sign of Sharp's syndrome. The diagnosis of mixed connective tissue disease was based on the combination of clinical signs and a high serum anti-RNP antinuclear antibody titre. The treatment of the pericarditis is base on prescription of corticosteroids, but non-steroidal anti-inflammatory drugs were sufficient in our case. Larger effusions may require corticosteroids and pericardial drainage. We report the value of immunological assays in the aetiological assessment of pleuropericarditis in young subjects.
混合性结缔组织病或夏普综合征是一类主要以关节、肌肉和皮肤表现形式出现的炎症性疾病。胸膜心包受累并不常见，很少作为首发症状出现，而心包填塞则极为罕见。本临床报告涉及一名22岁男性患者，其患有合并心包填塞的胸膜心包炎，这是夏普综合征的首发症状。混合性结缔组织病的诊断基于临床体征和高血清抗RNP抗核抗体滴度的结合。心包炎的治疗以使用皮质类固醇药物为基础，但在我们的病例中，非甾体类抗炎药就足够了。较大的积液可能需要使用皮质类固醇药物并进行心包引流。我们报告了免疫测定在年轻患者胸膜心包炎病因评估中的价值。
