Andreoni M, Goletti D, Pezzotti P, Pozzetto A, Monini P, Sarmati L, Farchi F, Tisone G, Piazza A, Pisani F, Angelico M, Leone P, Citterio F, Ensoli B, Rezza G
Infectious Disease Clinic, Tor Vergata University, S. Eugenio Hospital, Rome, Italy.
J Infect. 2001 Oct;43(3):195-9. doi: 10.1053/jinf.2001.0899.
To determine whether the incidence of HHV-8/KSHV infection and the risk of developing KS among organ transplant recipients differ by type of organ transplanted, we calculated the rate of HHV-8/KSHV seroconversion and the risk of developing KS among renal and liver transplant recipients.
The study population consisted of renal and liver transplant recipients recruited in two transplant centres in Rome, Italy. Both pre-transplant and post-transplant serum samples were available for all participants. The prevalence of HHV-8/KSHV infection before transplantation was calculated. To determine risk factors for infection, we calculated ORs and 95% CI. Seroconversion rates (i.e. attack rates) after transplantation were also calculated. Differences in attack rates were calculated using a binomial test for proportions.
Of the 130 participants, 21 (16.1%) were HHV-8/KSHV-positive before transplantation. Women were more likely to be infected than men, whereas no difference was observed by type of organ transplanted. Of the 109 initially negative individuals, 13 (11.9%) developed anti-HHV-8/KSHV antibodies after transplantation. The incidence of HHV-8/KSHV infection tended to be higher among liver transplant recipients. Four renal transplant recipients and none of the liver transplant recipients developed KS after transplantation. The risk of KS was higher among recipients who were already HHV-8/KSHV-positive before transplantation.
HHV-8/KSHV seroconversion rates appear to be higher among liver transplant recipients, compared to renal transplant recipients. However, renal transplant recipients tend to have a higher risk of KS. HHV-8/KSHV reactivation appears to play a greater role on the risk of KS than incident infections.
为了确定器官移植受者中HHV - 8/KSHV感染的发生率以及发生卡波西肉瘤（KS）的风险是否因移植器官类型而异，我们计算了肾移植和肝移植受者中HHV - 8/KSHV血清学转换率以及发生KS的风险。
研究人群包括在意大利罗马的两个移植中心招募的肾移植和肝移植受者。所有参与者均有移植前和移植后的血清样本。计算移植前HHV - 8/KSHV感染的患病率。为了确定感染的危险因素，我们计算了比值比（OR）和95%置信区间（CI）。还计算了移植后的血清学转换率（即发病率）。使用二项式比例检验计算发病率的差异。
130名参与者中，21名（16.1%）在移植前为HHV - 8/KSHV阳性。女性比男性更容易感染，而移植器官类型之间未观察到差异。在109名最初为阴性的个体中，13名（11.9%）在移植后产生了抗HHV - 8/KSHV抗体。肝移植受者中HHV - 8/KSHV感染的发生率往往更高。4名肾移植受者在移植后发生了KS，而肝移植受者均未发生。移植前已为HHV - 8/KSHV阳性的受者发生KS的风险更高。
与肾移植受者相比，肝移植受者中HHV - 8/KSHV血清学转换率似乎更高。然而，肾移植受者发生KS的风险往往更高。HHV - 8/KSHV再激活似乎比新发感染在KS风险中起更大作用。
