Roy K M, Goldberg D, Taylor A, Hutchinson S, MacDonald L, Wilson K S, Cameron S O
Scottish Centre for Infection and Environmental Health, Glasgow, UK.
J Infect. 2001 Oct;43(3):200-5. doi: 10.1053/jinf.2001.0908.
To determine the incidence of HCV infection in a selected population of Glasgow injectors during the mid-1990s, using a retrospective cohort design.
Unlinked anonymous anti-HCV testing was undertaken on serum residues collected from injecting drug users (IDUs) having two or more voluntary named HIV tests between 1993 and 1998.
Seventy-seven percent (164/212) of IDUs had detectable HCV antibody in their first specimen collected. Of the 44 IDUs who were initially HCV seronegative and had a subsequent specimen available for testing, 11 (25%) seroconverted, giving an estimated incidence of 28.4 per 100 person-years (95% CI 15.7-51.2); the incidence of infection was greatest amongst older males.
This study provides evidence of continuing transmission of HCV among Glasgow IDUs during an era of interventions to prevent the spread of bloodborne infections in this population and demonstrates the application of the unlinked anonymous testing approach to gauge incidence rather than prevalence of infection.
采用回顾性队列设计，确定20世纪90年代中期格拉斯哥特定注射人群中丙型肝炎病毒（HCV）感染的发生率。
对1993年至1998年间接受过两次或更多次自愿实名HIV检测的注射吸毒者（IDU）的血清残留进行不关联匿名抗HCV检测。
在首次采集的样本中，77%（164/212）的注射吸毒者检测到HCV抗体。在最初HCV血清学阴性且有后续样本可供检测的44名注射吸毒者中，11人（25%）发生血清转化，估计发病率为每100人年28.4例（95%可信区间15.7 - 51.2）；感染发生率在年龄较大的男性中最高。
本研究提供了证据，表明在为预防该人群血源感染传播而进行干预的时代，格拉斯哥注射吸毒者中HCV仍在持续传播，并证明了使用不关联匿名检测方法来评估感染的发病率而非患病率。
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