Devi Kh Sulochana, Brajachand Ng, Singh H Lokhendro, Singh Y Manihar
Department of Microbiology, RIMS, Imphal.
J Commun Dis. 2005 Mar;37(1):73-7.
Injecting drug users (IDUs) are at risk of parenterally transmitted diseases such as hepatitis B virus (HBV) hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. The present study was undertaken to find out the prevalence of HIV infection, HBV infection and HCV infection among IDUs of a deaddiction centre. Serum samples from 250, injecting drug users (IDUs) from a de-addiction centre were screened for HBsAg using immunochromatography, anti HCV antibody by 3rd generation ELISA test and anti HIV antibody by ELISA test and immunochromatographic rapid test during the period August to October 2002. One hundred and forty-nine (59.6%) IDUs were positive for HIV antibody, 226 (90.4%) were positive for anti HCV antibody and 27 (10.8%) were positive for HBsAg. There was co-infection of HIV, HBV and HCV in 15 (6%) of the IDUs. The Co-infection of HBV and HCV were found in 12 cases (4.8%) and Co-infection of HIV and HCV was found in 131 cases (52.4%). The IDUs were in sexually active age group with a risk of infection to their sexual partner. There is high prevalence of HCV and HIV infection and co-infection of both viruses among IDUs. Comprehensive public health interventions targeting this population and their sexual partners must be encouraged. Increase coverage of needle, syringe exchange programme (NSEP) to young and new IDUs is required before they are exposed to blood borne viruses.
注射吸毒者有感染经肠道外传播疾病的风险，如感染乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）。本研究旨在查明戒毒中心注射吸毒者中HIV感染、HBV感染和HCV感染的流行情况。2002年8月至10月期间，对一家戒毒中心的250名注射吸毒者的血清样本进行了检测，采用免疫层析法检测HBsAg，采用第三代酶联免疫吸附试验检测抗HCV抗体，采用酶联免疫吸附试验和免疫层析快速检测法检测抗HIV抗体。149名（59.6%）注射吸毒者HIV抗体呈阳性，226名（90.4%）抗HCV抗体呈阳性，27名（10.8%）HBsAg呈阳性。15名（6%）注射吸毒者同时感染了HIV、HBV和HCV。发现12例（4.8%）同时感染HBV和HCV，131例（52.4%）同时感染HIV和HCV。这些注射吸毒者处于性活跃年龄组，有感染其性伴侣的风险。注射吸毒者中HCV和HIV感染以及两种病毒的合并感染率很高。必须鼓励针对这一人群及其性伴侣的全面公共卫生干预措施。在年轻和新的注射吸毒者接触血源病毒之前，需要扩大针具和注射器交换计划（NSEP）的覆盖范围。
