Thisse Christine, Zon Leonard I
Institut de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, C. U. de Strasbourg, France.
Science. 2002 Jan 18;295(5554):457-62. doi: 10.1126/science.1063654.
Organs are specialized tissues used for enhanced physiology and environmental adaptation. The cells of the embryo are genetically programmed to establish organ form and function through conserved developmental modules. The zebrafish is a powerful model system that is poised to contribute to our basic understanding of vertebrate organogenesis. This review develops the theme of modules and illustrates how zebrafish have been particularly useful for understanding heart and blood formation.
器官是用于增强生理功能和环境适应性的特化组织。胚胎细胞通过保守的发育模块进行基因编程，以建立器官的形态和功能。斑马鱼是一个强大的模型系统，有望增进我们对脊椎动物器官发生的基本理解。本综述围绕模块这一主题展开，并阐述了斑马鱼在理解心脏和血液形成方面如何特别有用。
