Masi G, Mucci M, Favilla L, Millepiedi S
Division of Child Neurology and Psychiatry, IRCCS Stella Maris, Calambrone, University of Pisa, Italy.
Psychopathology. 2001 Sep-Oct;34(5):253-8. doi: 10.1159/000049318.
Anxiety disorders are common in patients with depressive disorders. This preliminary study investigated some clinical correlates of comorbidity between dysthymic disorder (DD) and generalized anxiety disorder (GAD) in a clinically referred sample of children and adolescents. After psychiatric evaluation, including a diagnostic clinical interview (DICA-R), 51 patients (25 males and 26 females, mean age 13.1 years) with an index diagnosis of DD associated with GAD were compared with 22 patients (13 males and 9 females, mean age 12.9 years) diagnosed as having pure DD. The comparison between subjects (DD with or without GAD) regarding the number of depressive symptoms did not show a significant main effect of group. Suicidal ideation was significantly more frequent in the group with comorbid GAD. Internalizing disorders were more frequent in the group of DD with GAD, while externalizing disorders were more frequent in the group without GAD. Functional impairment, assessed with the Children's Global Assessment Scale, did not show significant differences between the two groups. Data are discussed in the light of conceptualizations about the relationship between chronic anxiety and depressive disorders.
焦虑症在抑郁症患者中很常见。这项初步研究调查了在一个临床转诊的儿童和青少年样本中，恶劣心境障碍（DD）和广泛性焦虑症（GAD）共病的一些临床相关因素。经过包括诊断性临床访谈（DICA - R）在内的精神科评估，将51例（25例男性和26例女性，平均年龄13.1岁）以DD合并GAD为索引诊断的患者与22例（13例男性和9例女性，平均年龄12.9岁）被诊断为单纯DD的患者进行了比较。就抑郁症状数量而言，受试者（有或无GAD的DD患者）之间的比较未显示出显著的组间主效应。共病GAD的组中自杀观念明显更常见。内化障碍在DD合并GAD组中更常见，而外化障碍在无GAD组中更常见。用儿童总体评估量表评估的功能损害在两组之间未显示出显著差异。根据关于慢性焦虑与抑郁症之间关系的概念对数据进行了讨论。
