Lima Y B, Cury J A
Laboratório de Bioquímica Oral, Departamento de Ciências Fisiológicas, Universidade Estadual de Campinas, Piracicaba, SP, Brasil.
Rev Saude Publica. 2001 Dec;35(6):576-81. doi: 10.1590/s0034-89102001000600012.
To determine the total fluoride dose to which children were exposed during the critical age of developing dental fluorosis, in an optimally fluoridated region, having diet (liquids and solids) and dentifrice as fluoride sources.
For the pilot study, 39 children (aged 20 to 30 months) were selected from a day care center in Piracicaba, Brazil. They drank and ate food prepared with fluoridated water. To determine the total dose of fluoride exposure, duplicate-plate samples and products from tooth brushing were collected for two consecutive days, in four periods of the year. Fluoride was determined using an ion specific electrode. A 5% level of significance variance analysis (Anova) was carried out.
Children were exposed to a total fluoride dose of 0.090 mg/day/kg of body weight, of which 45% came from the diet and 55% from dentifrice.
Assuming 0.07 mg/kg as a threshold value of fluoride systemic exposure, children were exposed to a risk dose for dental fluorosis. Thus, measures to reduce fluoride intake at the studied age range would be recommended. Reducing the amount of dentifrice used for tooth brushing seems to be the best measure, given the risk/benefits of fluoride use from the public health perspective.
在一个氟化物最佳添加地区，确定以饮食（液体和固体）及牙膏作为氟化物来源时，儿童在牙氟中毒发育关键期所接触的总氟化物剂量。
在巴西皮拉西卡巴的一个日托中心选取39名儿童（年龄在20至30个月）进行初步研究。他们饮用并食用用含氟水制备的食物。为确定氟化物接触的总剂量，在一年中的四个时间段连续两天收集刷牙的重复平板样本和产物。使用离子特异性电极测定氟化物含量。进行了显著性水平为5%的方差分析（方差分析）。
儿童接触的氟化物总剂量为0.090毫克/天/千克体重，其中45%来自饮食，55%来自牙膏。
假设0.07毫克/千克为氟化物全身接触的阈值，儿童接触到了牙氟中毒的风险剂量。因此，建议采取措施减少所研究年龄范围内的氟化物摄入量。从公共卫生角度考虑氟化物使用的风险/益处，减少刷牙时牙膏的使用量似乎是最佳措施。
