Olgaard K
Acta Med Scand. 1975 Sep;198(3):213-8.
Plasma aldosterone concentration has been measured in 13 patients on regular hemodialysis, 7 anephric and 6 non-nephrectomized, following infusion of insulin-glucose. In all patients the plasma potassium fell about 16% within the first 60 min after the infusion, increasing again to about preinfusion levels within 180 min. All anephric patients showed a very low preinfusion value for plasma aldosterone (mean 33.3 pg/ml plasma), which increased significantly (p less than 0.01) after the infusion of insulin-glucose, to about 180% of the initial values, simultaneously with the fall in plasma potassium concentration. A significant inverse correlation (p less than 0.01) was found between changes in plasma aldosterone and potassium. The preinfusion in plasma aldosterone values were significantly higher (p less than 0.01) in the non-nephrectomized than in the anephric group--but of a wide range (26-700 pg/ml plasma). In this group the mean plasma aldosterone concentration showed a significant fall simultaneously with the fall in plasma potassium concentration, but with great variations between patients. There was a significant positive correlation (p less than 0.005) between the changes in plasma aldosterone and potassium. These studies indicate an extremely sensitive regulation of plasma aldosterone secretion in anephric patients, in all probability positively correlated to changes in intracellular adrenal potassium concentration.
对13例接受定期血液透析的患者（7例无肾，6例未行肾切除术）输注胰岛素 - 葡萄糖后测定了血浆醛固酮浓度。在所有患者中，输注后最初60分钟内血浆钾下降约16%，180分钟内又回升至输注前水平。所有无肾患者输注前血浆醛固酮值极低（平均血浆33.3 pg/ml），输注胰岛素 - 葡萄糖后显著升高（p<0.01），达到初始值的约180%，同时血浆钾浓度下降。血浆醛固酮和钾的变化之间存在显著负相关（p<0.01）。未行肾切除术组输注前血浆醛固酮值显著高于无肾组（p<0.01），但范围较宽（血浆26 - 700 pg/ml）。在该组中，平均血浆醛固酮浓度随血浆钾浓度下降而显著下降，但患者之间差异很大。血浆醛固酮和钾的变化之间存在显著正相关（p<0.005）。这些研究表明无肾患者血浆醛固酮分泌存在极其敏感的调节，很可能与细胞内肾上腺钾浓度的变化呈正相关。
