Côté G B, Edwards J H
Ann Hum Genet. 1975 Jul;39(1):51-9. doi: 10.1111/j.1469-1809.1975.tb00107.x.
A detailed description of the cytological mechanisms leading to autosomal trisomy shows that the proportion of trisomics carrying three alleles from three of their grandparents is bound to be greater than zero for any locus anywhere on a trisomic chromosome. The likelihood method used to estimate this proportion in pedigree data can be applied to the detection of linkage, or to investigations on the origin of trisomy when linkage is known.
对导致常染色体三体性的细胞学机制的详细描述表明，对于三体染色体上任何位置的任何基因座，携带来自其三位祖父母的三个等位基因的三体患者比例必然大于零。用于在系谱数据中估计该比例的似然法可应用于连锁检测，或在已知连锁时用于三体性起源的研究。
