Mellor J A, Miler J J
Dev Biol Stand. 1979;43:53-9.
Pseudomonas aeruginosa is a common pathogen in certain groups of patients. The use of antibiotics in these patients may be associated with toxic side effects, drug resistance and therapeutic failure. Pseudomonas vaccines have been prepared by many workers and one vaccine has been widely used in clinical trials. Administration of this vaccine was associated with a high incidence of toxic reactions. A new polyvalent pseudomonas vaccine has recently been prepared. We report the reactivity of this polyvalent vaccine in healthy volunteers and compare this with the reactivity of the earlier pseudomonas vaccine reported in the literature. The vaccine is at present being used in burned patients and has been associated with a significant reduction in mortality. We suggest that this new polyvalent vaccine has a low incidence of toxic effects and promises a considerable advance upon earlier vaccines.
铜绿假单胞菌是某些患者群体中的常见病原体。这些患者使用抗生素可能会产生毒副作用、耐药性和治疗失败等问题。许多研究人员制备了铜绿假单胞菌疫苗，其中一种疫苗已在临床试验中广泛使用。该疫苗的接种与高毒副反应发生率相关。最近制备了一种新的多价铜绿假单胞菌疫苗。我们报告了这种多价疫苗在健康志愿者中的反应性，并将其与文献中报道的早期铜绿假单胞菌疫苗的反应性进行比较。该疫苗目前正在烧伤患者中使用，并与死亡率的显著降低相关。我们认为这种新的多价疫苗毒副作用发生率低，有望比早期疫苗有相当大的进步。
