来自绢毛格木的吲哚和β-咔啉生物碱。

Indole and beta-carboline alkaloids from Geissospermum sericeum.

作者信息

Steele Jonathan C P, Veitch Nigel C, Kite Geoffrey C, Simmonds Monique S J, Warhurst David C

机构信息

Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, UK.

出版信息

J Nat Prod. 2002 Jan;65(1):85-8. doi: 10.1021/np0101705.

DOI:10.1021/np0101705

PMID:11809075

Abstract

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.

摘要

从绢毛格苏木树皮中获得了吲哚生物碱格苏索林（1）以及两种新衍生物，格苏索林N(4)-氧化物（2）和1,2-脱氢格苏索林（3），同时还得到了β-咔啉生物碱黄佩里任碱（4）。在氯喹抗性（K1）和氯喹敏感性（T9-96）恶性疟原虫中评估了这些化合物的体外抗疟活性。在人（KB）细胞系中测定了它们的细胞毒性。