Cury Marcia C, Lima W S, Guimarães M P, Carvalho M G
Laboratory of Parasitology, Federal University of Uberlândia, MG, Uberlândia, Brazil.
Vet Parasitol. 2002 Mar 1;104(2):139-49. doi: 10.1016/s0304-4017(01)00616-1.
Hematological and coagulation profiles were studied in crossbred dogs experimentally infected with Angiostrongylus vasorum. Two groups of five dogs were experimentally inoculated with 50 and 100 third stage infective larvae (L(3)) of A. vasorum per kilogram of body weight. A third group of five uninfected animals was used as control. One sample of 10 ml of blood was collected from each animal on the 10, 20, 30, and 45 days after inoculation (dai) and at 30-day intervals thereafter for the remainder of the 210-day experimental period. The blood sample was used for the complete hemogram and platelet count, as well as measurements of prothrombin time, partial thromboplastin time and factors V and VIII. Anemia was observed in infected dogs, 6 weeks after the infection. The eosinophils presented peaks in four periods after infection. Thrombocytopenia became accentuated on the 72 dai. Decreased prothrombin time activity and increased partial thromboplastin time were observed at the 6 and 9 weeks after infection and decreased of factors VIII and V activities occurred from 4 to 6 weeks after infection. It may be conclude that infection by A. vasorum in dogs may cause a discrete anemia during the acute phase which is probably regenerative. In addition, important hemostatic alterations due to the infection suggest a chronic intravascular consumption coagulopathy.
对实验感染管圆线虫的杂种犬的血液学和凝血指标进行了研究。将两组各五只犬按每千克体重分别接种50条和100条管圆线虫第三期感染性幼虫（L(3)）。第三组五只未感染动物作为对照。在接种后第10、20、30和45天（dai）从每只动物采集10毫升血样，此后在210天实验期的剩余时间里每隔30天采集一次。血样用于全血细胞计数和血小板计数，以及凝血酶原时间、部分凝血活酶时间和因子V及VIII的测定。感染犬在感染6周后出现贫血。嗜酸性粒细胞在感染后的四个时期出现峰值。血小板减少在感染后72天加重。感染后6周和9周观察到凝血酶原时间活性降低和部分凝血活酶时间延长，感染后4至6周因子VIII和V活性降低。可以得出结论，犬感染管圆线虫可能在急性期引起轻度贫血，可能是再生性的。此外，感染引起的重要止血改变提示慢性血管内消耗性凝血病。
