Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-Box 5003, N-1432, Ås, Norway.
Parasitology, Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-Box 5003, N-1432, Ås, Norway.
Acta Vet Scand. 2024 Sep 2;66(1):41. doi: 10.1186/s13028-024-00765-7.
A fifteen-month-old Pembroke Welsh corgi with respiratory distress, exercise intolerance, and moderate regenerative anemia was referred to The Norwegian University of Life Sciences, Small Animal Hospital.Hematology revealed moderate regenerative anemia without evidence of hemolysis. Thoracic radiographs showed a generalized mixed interstitial to alveolar lung pattern and enlarged pulmonary arteries. Changes suggestive of moderate pulmonary hypertension were noted on echocardiography. Baermann fecal diagnostic flotation identified large numbers of Angiostrongylus vasorum larvae, and the AngioDetect serological antigen test was positive. The dog was treated with a two-week course with fenbendazole (51 mg/kg q24h po) and topical imidacloprid/moxidectin (250 mg/62.5 mg) and a one-week course with sildenafil (0.45 mg/kg q12h po). Complete clinical, clinicopathological and echocardiographic resolution was observed after only four weeks. Rapid improvement of echocardiographic abnormalities in cases with suspected pulmonary hypertension is not usually reported in cases with angiostrongylosis.Infection with A. vasorum should be considered in dogs with respiratory signs and bleeding tendencies, even in countries with no endemic history or reported cases.
一只 15 个月大的彭布罗克威尔士柯基犬,出现呼吸窘迫、运动不耐受和中度再生性贫血,被转诊至挪威生命科学大学小动物医院。血液学检查显示中度再生性贫血,无溶血证据。胸部 X 光片显示弥漫性混合性间质性至肺泡性肺模式和肺动脉增大。超声心动图显示中度肺动脉高压的变化。Baermann 粪便诊断漂浮法发现大量血管圆线虫幼虫,AngioDetect 血清抗原检测呈阳性。该犬接受了两周的芬苯达唑(51mg/kg,q24h,po)和局部伊维菌素/莫昔克丁(250mg/62.5mg)治疗,以及一周的西地那非(0.45mg/kg,q12h,po)治疗。仅四周后,临床症状、临床病理学和超声心动图完全缓解。在疑似肺动脉高压的病例中,通常不会报告血管圆线虫病引起的超声心动图异常迅速改善。在没有地方性病史或报告病例的国家,即使有呼吸症状和出血倾向的犬也应考虑到血管圆线虫感染。