Niimi Yayoi, Kawana Seiji
Department of Dermatology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-0086 Japan. niimiyayoi/
Eur J Dermatol. 2002 Jan-Feb;12(1):90-2.
We report two cases of desmoplastic trichoepithelioma. One case was associated with compound nevus and the other case with ossification. Desmoplastic trichoepithelioma and nevus cell nevus are assumed to be a combined malformation. In our case 1, clinical and histological findings indicate that nevus cell nevus preceded desmoplastic trichoepithelioma and the latter developed in the lesion of the former. Ossification was reported to be associated with desmoplastic trichoepithelioma in 6% of cases. However, case reports of this combination with a detailed description are extremely rare. We speculate that the mechanism of ossification in this tumor must be related to foreign-body reactions caused by ruptured horn cysts.
我们报告两例促结缔组织增生性毛发上皮瘤。一例与复合痣相关，另一例与骨化相关。促结缔组织增生性毛发上皮瘤和痣细胞痣被认为是一种联合畸形。在我们的病例1中，临床和组织学结果表明痣细胞痣先于促结缔组织增生性毛发上皮瘤出现，后者在前者的病变中发展。据报道，6%的促结缔组织增生性毛发上皮瘤病例与骨化有关。然而，关于这种组合并伴有详细描述的病例报告极为罕见。我们推测，该肿瘤中骨化的机制必定与破裂的角囊肿引起的异物反应有关。
