Brownstein M H, Starink T M
Laboratory of Dermatopathology, Port Washington, NY 11050.
J Am Acad Dermatol. 1987 Sep;17(3):489-92. doi: 10.1016/s0190-9622(87)70234-5.
We studied 13 desmoplastic trichoepitheliomas associated with intradermal nevi. Ten intradermal nevi were found among 76 new cases of desmoplastic trichoepithelioma (13%); three additional examples of the combined malformation were seen in consultation. Clinically, desmoplastic trichoepithelioma associated with an intradermal nevus was typically a small, firm or hard, sometimes annular, nodule on the face, particularly the cheek, of a relatively young woman. Microscopically, the combined malformation contained narrow strands of basaloid cells and keratinous cysts in a desmoplastic stroma, intimately mixed with intradermal nests of nevocytes. Melanocytic nevi have been associated with epidermal hyperplasia resembling seborrheic keratoses, follicular cysts, trichostasis spinulosa, syringomas, basal cell carcinomas, and hair follicle formation on the soles. The frequency of the occurrence of intradermal nevus with desmoplastic trichoepithelioma and the close anatomic association of the two elements may indicate that this combined malformation is another example of epithelial induction by melanocytic nevi.
我们研究了13例与皮内痣相关的促结缔组织增生性毛发上皮瘤。在76例新的促结缔组织增生性毛发上皮瘤病例中发现了10例皮内痣（13%）；会诊时又发现了另外3例合并畸形的病例。临床上，与皮内痣相关的促结缔组织增生性毛发上皮瘤通常表现为相对年轻女性面部尤其是面颊部的一个小的、质地硬或坚硬、有时呈环状的结节。显微镜下，这种合并畸形在促结缔组织增生性间质中含有窄条的基底样细胞和角质囊肿，并与皮内痣细胞巢紧密混合。黑素细胞痣与类似脂溢性角化病、毛囊囊肿、棘状毛发、汗管瘤、基底细胞癌的表皮增生以及足底的毛囊形成有关。皮内痣与促结缔组织增生性毛发上皮瘤同时出现的频率以及二者紧密的解剖学关联可能表明这种合并畸形是黑素细胞痣诱导上皮形成的又一实例。
