González-Vela M Carmen, Val-Bernal J Fernando, Garcia-Alberdi Eva, González-López Marcos A, Fernández-Llaca J Héctor
Department of Anatomical Pathology, Service of Dermatology, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
Am J Dermatopathol. 2007 Feb;29(1):92-5. doi: 10.1097/DAD.0b013e31802e462f.
Melanocytic nevi have been associated with epidermal hyperplasia, adnexal hyperplasia with follicular and sebaceous differentiation, cysts, and tumors of epidermal or adnexal origin. We report a combined cutaneous hamartoma in a 29-year-old woman that comprised a trichoadenoma within an intradermal melanocytic nevus. Clinical diagnosis was a malignant transformation of a melanocytic nevus. Histopathologically, multiple keratinous cysts together with solid islands or masses of eosinophilic epithelial cells were closely intermingled with the nevus cells. Occasional nests of basaloid cells were present. Although to our knowledge this association has not been previously reported, it is worth considering that trichoadenoma and desmoplastic trichoepithelioma are the two ends of a spectrum of lesions. This combined hamartoma reported herein is important because growth of these lesions could be clinically misinterpreted as malignant transformation of a preexisting lesion. Histologic study will reveal the correct diagnosis in such cases.
黑素细胞痣与表皮增生、具有毛囊和皮脂腺分化的附属器增生、囊肿以及表皮或附属器来源的肿瘤有关。我们报告了一名29岁女性的复合型皮肤错构瘤，其由真皮内黑素细胞痣内的毛发腺瘤组成。临床诊断为黑素细胞痣恶变。组织病理学检查显示，多个角质囊肿以及实性的嗜酸性上皮细胞岛或团块与痣细胞紧密交织在一起。偶尔可见基底样细胞巢。尽管据我们所知这种关联此前尚未见报道，但值得考虑的是，毛发腺瘤和促结缔组织增生性毛发上皮瘤是一系列病变的两端。本文报道的这种复合型错构瘤很重要，因为这些病变的生长在临床上可能会被误解为原有病变的恶变。组织学研究将为此类病例揭示正确的诊断。
