Kinkor Z, Benková K
Oddĕlení patologie Fakultní nemocnice Na Bulovce, Praha.
Cesk Patol. 2001 Nov;37(4):168-71.
The paper discusses two unusual cases of solitary skeletal plasmacytoma and multiple myeloma presenting clinically as a metastatic disease in cervical lymph nodes. The pathology report of lymph node plasmacytoma initiated an extensive clinical search for eventual discovery of skeletal disease in both patients. We are not aware of any report in the literature dealing with this issue (Medline 1970-2000). The early involvement of lymph nodes by plasmacytoma with the appearance of undifferentiated neoplasm is challenging and poses great difficulties in correct diagnosis; this is almost impossible from hematoxylin eosin slides. The problem is that one has to think about the rare possibility of metastasing plasmacytoma in differential diagnosis of anaplastic tumors in lymph nodes. Immunohistochemistry and clinical records are very helpful in making a final diagnosis.
本文讨论了两例罕见的孤立性骨浆细胞瘤和多发性骨髓瘤病例，其临床表现为颈部淋巴结转移性疾病。淋巴结浆细胞瘤的病理报告促使对两名患者进行了广泛的临床检查，最终发现了骨骼疾病。我们未在文献（1970 - 2000年医学索引）中找到任何关于此问题的报道。浆细胞瘤早期累及淋巴结并表现为未分化肿瘤，这具有挑战性，在正确诊断方面存在很大困难；仅通过苏木精 - 伊红染色切片几乎无法诊断。问题在于，在鉴别诊断淋巴结间变性肿瘤时，必须考虑到浆细胞瘤转移这种罕见的可能性。免疫组织化学和临床记录对做出最终诊断非常有帮助。
