Lentino Joseph R, Krasnicka Barbara
Section of Infectious Diseases (111P), Medical Service, Cooperative Studies Program Coordinating Center, Edward Hines, Jr. VA Hospital, Hines, IL 60141, USA.
Int J Antimicrob Agents. 2002 Jan;19(1):61-6. doi: 10.1016/s0924-8579(01)00472-1.
This investigation assessed the impact of initial empirical antimicrobial therapy on the outcome of therapy for community acquired pneumonia (CAP) patients and on patients' length of stay (LOS) in the hospital. Hospital records for 165 patients with pneumonia admitted to the Edward Hines, Jr. VA Hospital between 1 October 1997, and 31 March 2000, were reviewed. Criteria for CAP were met for 92 of 165 patients. Comparisons were made between patients treated with azithromycin and with other parenteral antibiotics (the reference group). No statistical differences were observed between the treatment groups for the risk factors. The azithromycin group patients were slightly older with a mean age of 69 years versus 66 years (P=0.23). Patients treated with parenteral azithromycin had on average, a shorter length of hospitalization namely 4.6 days compared with 9.7 days for patients treated with the other antibiotics (log-rank test, P=0.0001). In order to make the two groups of patients more alike we considered patients' data set without intensive care unit (ICU) admissions. The conclusion was the same namely azithromycin monotherapy was associated with a decreased duration of hospital stay.
本研究评估了初始经验性抗菌治疗对社区获得性肺炎（CAP）患者治疗结局及住院时间（LOS）的影响。回顾了1997年10月1日至2000年3月31日期间入住小爱德华·海因斯退伍军人医院的165例肺炎患者的医院记录。165例患者中有92例符合CAP标准。对接受阿奇霉素治疗的患者与接受其他胃肠外抗生素治疗的患者（参照组）进行了比较。各治疗组在危险因素方面未观察到统计学差异。阿奇霉素组患者年龄稍大，平均年龄为69岁，而另一组为66岁（P = 0.23）。接受胃肠外阿奇霉素治疗的患者平均住院时间较短，为4.6天，而接受其他抗生素治疗的患者为9.7天（对数秩检验，P = 0.0001）。为使两组患者更具可比性，我们考虑了未入住重症监护病房（ICU）患者的数据集。结论相同，即阿奇霉素单药治疗与住院时间缩短相关。
