（-）-长春二氢吲哚6,16-二取代类似物的细胞毒性

Cytotoxicity of 6,16-disubstituted analogues of (-)-vincadifformine.

作者信息

Lewin Guy, Hocquemiller Reynald, Schaeffer Corinne, Lambert Pierre-Hervé, Léonce Stéphane, Pierré Alain

机构信息

Laboratoire de Pharmacognosie (BIOCIS, UPRES-A 8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex,

出版信息

Bioorg Med Chem Lett. 2002 Feb 11;12(3):371-4. doi: 10.1016/s0960-894x(01)00757-0.

DOI:10.1016/s0960-894x(01)00757-0

PMID:11814799

Abstract

Eight analogues of (-)-16-chloro-1-dehydro-6S-bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure-activity relationships within this series.

摘要

合成了(-)-16-氯-1-脱氢-6S-溴长春叶胺1的8种类似物，并在L1210细胞培养中评估了它们的细胞毒性。没有一种新化合物比1更具活性，但在C6、C16和C10处芳环上的修饰揭示了该系列内的构效关系。