[具有修饰色胺链的阿朴菲吲哚生物碱的细胞毒性]

[Cytotoxicity of aspidospermane indole alkaloids with a modified tryptamine chain].

作者信息

Lewin G

机构信息

Laboratoire de Pharmacognosie, Faculté de Pharmacie, Caen, France.

出版信息

J Nat Prod. 1995 Jul;58(7):1089-91. doi: 10.1021/np50121a018.

DOI:10.1021/np50121a018

PMID:7561901

Abstract

Eight synthetic indole alkaloids with the aspidospermane structure have ben evaluated for cytotoxicity in the L-1210 cell culture test system. Two of them (compounds 9 and 5), bearing a modified tryptamine chain, were significantly active (IC50 values of 0.7 and 3.1 microM, respectively).

摘要

已在L - 1210细胞培养测试系统中对8种具有阿朴菲烷结构的合成吲哚生物碱进行了细胞毒性评估。其中两种（化合物9和5）带有修饰的色胺链，具有显著活性（IC50值分别为0.7和3.1 microM）。