新型氨基环戊[c]噻吩酮的合成及其对L1210白血病的细胞毒性活性
Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones.
作者信息
Alsaidi A, al Shargapi S, Dallemagne P, Carreiras F, Gauduchon P, Rault S, Robba M
机构信息
Centre d'Etudes et de Recherche sur le Médicament de Normandie (Laboratoire de Chimie Thérapeutique) U.F.R. des Sciences Pharmaceutiques, Caen, France.
出版信息
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1605-8. doi: 10.1248/cpb.42.1605.
PMID:7954912
Abstract
Synthesis of some new hydroxyaminocyclopenta[c]thiophenones was achieved via halogenation reaction, then formation and finally cleavage of an aziridino ring. The in vitro cytotoxic activity of these compounds was evaluated against L1210 leukemia. The importance of the ketohydroxyethylamino sequence for their activities is discussed.
摘要
通过卤化反应，然后形成并最终裂解氮丙啶环，实现了一些新型羟基氨基环戊并[c]噻吩酮的合成。评估了这些化合物对L1210白血病的体外细胞毒性活性。讨论了酮羟基乙氨基序列对其活性的重要性。
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