Department of Life Sciences, Presidency University, Kolkata, West Bengal, India
Department of Otorhinolaryngology-Head and Neck Surgery, and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Virol. 2019 Jun 14;93(13). doi: 10.1128/JVI.00238-19. Print 2019 Jul 1.
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis.
爱泼斯坦-巴尔病毒（EBV）是一种广泛存在的γ疱疹病毒，无症状感染世界上大多数人口。在免疫功能低下的情况下，EBV 可引发上皮和淋巴来源的人类癌症。EBV 的致癌潜能通过感染和将静止的 B 细胞转化为淋巴母细胞系（LCL）来证明。这些细胞系，以及使用遗传工程病毒颗粒进行原发性感染，并结合最近的技术进步，阐明了 EBV 诱导的 B 细胞淋巴瘤发生的潜在机制。
