Racić G, Petri N M, Andrić D
Clinical Hospital Split, Croatia, Department of ENT.
Int Marit Health. 2001;52(1-4):74-84.
Sudden hearing loss is a sensorineural hearing impairment, which develops over a period of few hours to a few days. Several theories have been proposed regarding the development of sudden sensorineural hearing loss. The incidence of sudden sensorineural hearing loss has been reported to range from 5 to 20 per 100,000 persons per year. Hearing loss is treated with drugs that provide better blood supply to the inner ear and decrease inflammation. The aim of this study is to examine the influence of hyperbaric oxygen therapy in treating sudden sensorineural hearing loss. The beneficial effects of HBO2 on sudden sensorineural hearing loss are probably achieved by an increase in the distribution of O2 dissolved per volume unit of blood circulating trough the regions affected by the lack of oxygen. Sessions were performed on 17 patients, with sudden sensorineural hearing loss that began within 10 days prior to the tests. In the hyperbaric chamber, all patients breathed 100% oxygen at 2.8 bars, for 60 minutes twice a day, either until recovered or for a maximum of 30 sessions. Of the total number of study participants, 12 were male and 5 were female, and their average age was 35.3 years (range: 18 to 68). Before the therapy, an average hearing value was obtained out of five basic frequencies. Hearing was found to be in the range of 61-93 dB in 12 patients, while 5 patients had hearing in the range of 41-60 dB. Following therapy with hyperbaric oxygen, the hearing level of 14 patients was within the range of 0-26 dB, two patients' hearing level increased to 27-40 dB, and one patient's hearing level remained in the range of 41-60 dB. The average hearing level for all patients and for all five basic frequencies was 67.8 dB before therapy, in comparison with 21.6 dB after oxygen therapy (p=0.0003). The average number of sessions in the hyperbaric chamber was 11.9 (range: 5 to 20). The therapy was taken well by all patients. The results of this study, as well as the results of similar studies performed by other authors, indicate for the necessity of performing an additional prospective, random, double-blind study of the effects of hyperbaric oxygen therapy on sudden sensorineural hearing loss, on a large number of patients.
突发性听力损失是一种感音神经性听力障碍，其在数小时至数天的时间内发展形成。关于突发性感音神经性听力损失的发病机制，已经提出了几种理论。据报道，突发性感音神经性听力损失的发病率为每年每10万人中有5至20例。听力损失通过使用能改善内耳血液供应并减轻炎症的药物进行治疗。本研究的目的是检验高压氧疗法对治疗突发性感音神经性听力损失的影响。高压氧对突发性感音神经性听力损失的有益作用可能是通过增加每单位体积循环血液中溶解氧在受缺氧影响区域的分布来实现的。对17例在测试前10天内开始出现突发性感音神经性听力损失的患者进行了治疗疗程。在高压氧舱中，所有患者在2.8巴的压力下呼吸100%的氧气，每天两次，每次60分钟，直至康复或最多进行30个疗程。在所有研究参与者中，男性12例，女性5例，平均年龄为35.3岁（范围：18至68岁）。在治疗前，从五个基本频率中获得平均听力值。发现12例患者的听力在61 - 93分贝范围内，而5例患者的听力在41 - 60分贝范围内。经过高压氧治疗后，14例患者的听力水平在0 - 26分贝范围内，2例患者的听力水平提高到27 - 40分贝，1例患者的听力水平仍在41 - 60分贝范围内。治疗前所有患者以及所有五个基本频率的平均听力水平为67.8分贝，相比之下，氧疗后为21.6分贝（p = 0.0003）。在高压氧舱中的平均治疗疗程数为11.9个（范围：5至20个）。所有患者对该治疗耐受性良好。本研究的结果以及其他作者进行的类似研究的结果表明，有必要对大量患者进行一项关于高压氧疗法对突发性感音神经性听力损失影响的额外前瞻性、随机、双盲研究。
