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本文引用的文献

1
[Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa].[结直肠癌及正常结肠黏膜中p16基因的甲基化状态]
Zhonghua Bing Li Xue Za Zhi. 2000 Apr;29(2):95-8.
2
Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa.结直肠癌及正常结肠黏膜中p16基因的甲基化状态
World J Gastroenterol. 1999 Oct;5(5):451-454. doi: 10.3748/wjg.v5.i5.451.
3
DNA methylation and carcinogenesis in digestive neoplasms.消化系统肿瘤中的DNA甲基化与致癌作用
World J Gastroenterol. 1998 Apr;4(2):174-177. doi: 10.3748/wjg.v4.i2.174.
4
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.K-ras和p16基因变异预示着人类结直肠癌的预后不良。
J Clin Oncol. 2001 Jan 15;19(2):299-304. doi: 10.1200/JCO.2001.19.2.299.
5
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.非小细胞肺癌中多个基因的异常启动子甲基化
Cancer Res. 2001 Jan 1;61(1):249-55.
6
High frequency of homozygous deletion and methylation of p16(INK4A) gene in oral squamous cell carcinomas.口腔鳞状细胞癌中p16（INK4A）基因纯合缺失和甲基化的高频率
Cancer Lett. 2001 Feb 26;163(2):221-8. doi: 10.1016/s0304-3835(00)00699-6.
7
Methylation of the p16(Ink4a) tumor suppressor gene 5'-CpG island in breast cancer.乳腺癌中p16（Ink4a）肿瘤抑制基因5'-CpG岛的甲基化
Cancer Lett. 2001 Feb 10;163(1):59-69. doi: 10.1016/s0304-3835(00)00674-1.
8
Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa.结直肠癌及正常结肠黏膜中CDKN2a/p16基因的突变、甲基化与表达
Cancer Lett. 2001 Feb 10;163(1):17-23. doi: 10.1016/s0304-3835(00)00652-2.
9
Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.肝脏肝内胆管癌中p16(INK4A)改变及K-ras突变的频率
Gut. 2000 Nov;47(5):721-7. doi: 10.1136/gut.47.5.721.
10
Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer.
Cancer Res. 2000 Aug 1;60(15):4021-5.

结直肠癌中p16基因甲基化与杜克分期相关。

p16 gene methylation in colorectal cancers associated with Duke's staging.

作者信息

Yi J, Wang Z W, Cang H, Chen Y Y, Zhao R, Yu B M, Tang X M

机构信息

Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing South Road, Shanghai 200025, China.

出版信息

World J Gastroenterol. 2001 Oct;7(5):722-5. doi: 10.3748/wjg.v7.i5.722.

DOI:10.3748/wjg.v7.i5.722
PMID:11819863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4695583/
Abstract

AIM

To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers.

METHODS

Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens.

RESULTS

p16 methylation was detected in 42% of the tumors.Dukes'staging was associated with p16 methylation status.p16 methylation occurred more frequently in Dukes'C and D patients (75.9%) than in Dukes'A and B patients (12.1%).

CONCLUSION

p16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer, and it might be linked to poor prognosis.

摘要

目的

探讨p16肿瘤抑制基因启动子区CpG岛甲基化与结直肠癌临床病理特征的相关性。

方法

采用甲基化特异性PCR（MSP）检测62例散发性结直肠癌标本的p16甲基化情况。

结果

42%的肿瘤检测到p16甲基化。Dukes分期与p16甲基化状态相关。p16甲基化在Dukes' C期和D期患者中（75.9%）比在Dukes' A期和B期患者中（12.1%）更常见。

结论

p16甲基化在一部分结直肠癌的致癌过程中起作用，并且可能与预后不良有关。