Vekshina N L, Sovetov A N
Biull Eksp Biol Med. 1975 Aug;80(8):20-3.
A spectrofluorometric study of the changes in serotonin and noradrenalin content was carried out in the cortex of large hemispheres, the hypothalamus and the midbrain on the 5th-6th day after creation of a pathological focus in the area of the occipital portion of the cortex in 12 cats. Diffuse changes in the bioelectrical activity of the brain were revealed on the EEG at this period: there appeared peak-like variations and slow waves of increased amplitude. There was noted a marked decrease in serotonin content in the cortex of the large hemispheres with the prevalance of an effect in the area directly adhering to the focus of affection. A tendency to reduction in serotonin level was revealed in the hypothalamus and the midbrain. The content of noradrenalin in the mentioned structures of the brain showed no significant change. The significance of the serotoninergic structures of the brain in the mechanisms participating in the restoration of the functional condition of the brain after its experimental injury is discussed.
对12只猫在枕叶皮质区域形成病理病灶后第5 - 6天，对其大脑半球皮质、下丘脑和中脑中血清素和去甲肾上腺素含量的变化进行了荧光分光光度研究。在此期间脑电图显示大脑生物电活动有弥漫性变化：出现峰状变异和振幅增加的慢波。发现大脑半球皮质中的血清素含量显著降低，在直接毗邻病变灶的区域影响最为明显。下丘脑和中脑也显示出血清素水平有降低趋势。上述脑结构中的去甲肾上腺素含量未显示出显著变化。本文讨论了脑内血清素能结构在参与实验性脑损伤后功能状态恢复机制中的意义。
