[Monoamine content in the motor region of the cerebral cortex following damage to the symmetrical area of the opposite hemisphere].

On 8 cats chronic experiments were carried out to determine (spectrofluorometrically) the content of serotonin, dopamine, and noradrenaline in the sigmoid region of the left cerebral hemisphere on the second, third, forth, fifth, eighth days after the removal of the cortex of the symmetrical region of the right hemisphere. On the second day, at the time of maximum disorders of the locomotor function, dopamine content was found to decrease; there was also a tendency to reduction of noradrenaline and serotonin. On the third, and the fifth--eighth days, at the period of the locomotor activity restoration, there was a rise of serotonin content, whereas dopamine content remained low, and noradrenaline content rose considerably. The role of biochemical changes in the motor region in the mechanisms of locomotor function restoration following symmetrical damage of the large hemisphere cortex is discussed.