Pollack Ian F, Biegel Jaclyn, Yates Allan, Hamilton Ronald, Finkelstein Sydney
Department of Neurosurgery, Children"s Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. pollaci@
Curr Oncol Rep. 2002 Mar;4(2):114-22. doi: 10.1007/s11912-002-0072-5.
Brain tumors as a group are the most common solid tumors of childhood and currently have the highest mortality rate. A major emphasis has historically been placed on stratifying therapy for these tumors based on histologic and clinical prognostic factors. However, with the increasing application of molecular approaches to refine the categorization of these tumors, it has become apparent that histologically comparable lesions may exhibit diverse patterns of gene expression and genomic alterations, which may correspond with important prognostic distinctions. This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy.
脑肿瘤作为一个整体是儿童期最常见的实体瘤，目前死亡率最高。历史上主要强调根据组织学和临床预后因素对这些肿瘤进行分层治疗。然而，随着分子方法越来越多地用于完善这些肿瘤的分类，显然组织学上相似的病变可能表现出不同的基因表达模式和基因组改变，这可能与重要的预后差异相关。本文总结了这些观察结果，并讨论了它们如何以初步方式应用，作为儿童脑肿瘤治疗风险适应性分层的基础。
