Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Hematol Oncol Clin North Am. 2012 Aug;26(4):715-32. doi: 10.1016/j.hoc.2012.05.004. Epub 2012 Jun 22.
Contemporary neuropathology plays a key role in the multidisciplinary management of brain tumor patients, in part due to increased supplementation of histopathological assessments by molecular diagnostic tests involving brain tumor tissue. Several molecular tests have become routine for clinical practice, and not only contribute to a refinement of tumor classification, but also aid in improved prediction of prognosis and in development of a tailored approach to therapy. This review provides an overview of classification and grading of brain tumors, particularly neuroepithelial tumors, and describes genetic/epigenetic changes that have gained clinical significance for molecular diagnostic testing.
当代神经病理学在脑肿瘤患者的多学科管理中起着关键作用，部分原因是通过涉及脑肿瘤组织的分子诊断测试，对组织病理学评估进行了更多的补充。一些分子测试已成为临床实践的常规手段，它们不仅有助于提高肿瘤分类的准确性，还有助于改善预后预测，并为制定个体化治疗方法提供依据。本文综述了脑肿瘤，特别是神经上皮肿瘤的分类和分级，并描述了在分子诊断测试中具有临床意义的遗传/表观遗传变化。
