Rosenbach Keith A, Allison Robert, Nadler Jeffrey P
Division of Infectious Diseases, Tampa General Hospital, Infectious Diseases Center, University of South Florida, Tampa, FL, 33601, USA.
Clin Infect Dis. 2002 Mar 1;34(5):686-92. doi: 10.1086/338255. Epub 2002 Jan 25.
Complex treatment schedules for human immunodeficiency virus (HIV) disease, which can have a high pill burden and can include multiple daily doses, in addition to the adverse effects that the medications can cause, may reduce patient adherence to therapy. Reduced adherence prevents achievement of the desired goal of full suppression of HIV replication, and it also promotes the development of drug-resistant strains of HIV. Thus, the focus of treatment has shifted toward the use of simpler regimens. A major strategy is the development of medications and regimens for management of HIV infection that can be taken once per day. The goal of such a strategy is to improve convenience and optimize adherence, which is critical to maximizing the likelihood of sustained virologic response. Several studies involving regimens with once-daily dosing, which have involved both available agents and agents in development, have yielded promising results. In comparison with standard regimens, which involve dosing 2 or 3 times daily, the regimens with once-daily dosing improved tolerability while maintaining efficacy and safety. The results are expected to increase adherence rates among patients, reduce the incidence of antiretroviral-resistant variants of HIV, and improve the clinical outcomes during a prolonged treatment course.
人类免疫缺陷病毒（HIV）疾病的复杂治疗方案可能会增加患者的服药负担，每日服药次数可能多达数次，且药物会产生不良反应，这些都可能导致患者治疗依从性降低。依从性降低不仅无法实现完全抑制HIV复制的预期目标，还会促使HIV耐药毒株的产生。因此，治疗重点已转向使用更简单的治疗方案。一项主要策略是研发用于治疗HIV感染的药物和方案，使其能够每日服用一次。这一策略的目标是提高便利性并优化依从性，这对于最大程度提高持续病毒学应答的可能性至关重要。多项涉及每日一次给药方案的研究，涵盖了现有药物和正在研发的药物，均取得了令人鼓舞的结果。与每日给药2次或3次的标准方案相比，每日一次给药方案在维持疗效和安全性的同时提高了耐受性。预计这些结果将提高患者的依从率，降低HIV抗逆转录病毒耐药变异株的发生率，并改善长期治疗过程中的临床结局。
