Chen You, Peng Dan, Sun Cai-jiang, Wang Wan-chun, Li Ju-yuan, Zhang Wei
Department of Orthopedic Surgery, Second Xiangya Hospital, Zhongnan University, Changsha Hunan, P. R. China 410011.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Jan;16(1):19-20.
To evaluate the clinical effect of sodium hyaluronate (SH) intra-articular injection in treatment of degenerative osteoarthritis (DOA) of knees.
One hundred patients (116 knees) suffered from DOA were treated by SH injection intra-articularly once a week for three times. According to Lysholm scoring, clinical signs such as pain, swelling, excludes, range of movement (ROM), and the ability of walking, going upstairs and downstairs, squatting, running, were assessed before and after treatment.
Ninety-six cases were followed up for 1 to 6 months. There were obvious improvements in the signs and function of knee in 39 patients (40.6%), only some improvements in 48 patients (50.0%), and no obvious improvements in other 9 patients (9.4%). The total effectiveness rate was 74.0%. No toxic or side effect was observed.
Intraarticular injection of SH has a positive effect in relief of clinical symptoms and in improvement of articular function of DOA of knee.
评估透明质酸钠（SH）关节腔内注射治疗膝关节退行性骨关节炎（DOA）的临床效果。
100例（116膝）DOA患者接受SH关节腔内注射治疗，每周1次，共3次。根据Lysholm评分，在治疗前后评估疼痛、肿胀、压痛、活动范围（ROM）以及行走、上下楼梯、下蹲、跑步等临床体征。
96例患者随访1至6个月。39例患者（40.6%）膝关节体征和功能有明显改善，48例患者（50.0%）仅有部分改善，另外9例患者（9.4%）无明显改善。总有效率为74.0%。未观察到毒副作用。
关节腔内注射SH对缓解膝关节DOA的临床症状和改善关节功能有积极作用。
