Yan Li, Liang Zhao, Wen Jian-Min, Li Ding, Xun Shu-Ying, Li Zhi-Yao
2nd Department of Joint, Wangjing Hospital, China Academy of Chinese Medical Science, Beijing 100102, China.
Zhongguo Gu Shang. 2010 Jul;23(7):547-50.
To retrospectively analyze the long-term efficacy of intra-articular injection with sodium hyaluronate for the treatment of knee osteoarthritis.
From January 2006 to August 2007,120 patients (181 knees) with knee osteoarthritis, (mild 61 knees, moderate 72 knees, severe 48 knees), were treated by intra-articular injection with sodium hyaluronate, 2 ml every week for 5 weeks. The clinical effects were analyzed according to VAS, JOA scoring before treatment, at the 1 month, 1, 2 years after treatment.
(1) VAS scores were respectively (7.26 +/- 1.83), (1.85 +/- 1.21), (2.54 +/- 1.40), (3.07 +/- 1.51) scores before treatment, at the 1 month, 1 and 2 years after treatment. There was significant difference between every post-treatment and pre-treatment. (2) JOA scoring of knee function was respectively (18.7 +/- 6.6), (84.3 +/- 15.5), (75.4 +/- 22.4), (64.8 +/- 25.6) scores before treatment, at the 1 month, 1 and 2 years after treatment. There was significant difference between every post-treatment and pre-treatment. (3) Assessment of long-term efficacy among 181 knees who were followed up 1 year, 70 cases got excellent results, 54 good, 34 fair and 23 poor. Those who were followed up 2 years,40 cases got excellent results, 54 good, 53 fair and 34 poor. Knee function became poor along with time-lapse. The efficiency was respectively 86.89% (53/61), 79.17% (57/72), 54.17% (26/48) in mild knees, moderate knees, severe knees at the 2 years after treatment.
The long-term efficacy of intra-articular injection with sodium hyaluronate is satisfactory in treating knee osteoarthritis. The efficacy is better for mild and moderate osteoarthritis than for the severe osteoarthritis. The short-term efficacy is acceptable and the long-term one is worse for the severe knees.
回顾性分析关节腔内注射透明质酸钠治疗膝关节骨关节炎的长期疗效。
2006年1月至2007年8月，120例（181膝）膝关节骨关节炎患者（轻度61膝，中度72膝，重度48膝）接受关节腔内注射透明质酸钠治疗，每周2 ml，共5周。根据治疗前、治疗后1个月、1年、2年的视觉模拟评分法（VAS）、日本骨科学会（JOA）评分分析临床疗效。
（1）治疗前、治疗后1个月、1年、2年的VAS评分分别为（7.26±1.83）、（1.85±1.21）、（2.54±1.40）、（3.07±1.51）分。各治疗后与治疗前比较差异有统计学意义。（2）膝关节功能JOA评分治疗前、治疗后1个月、1年、2年分别为（18.7±6.6）、（84.3±15.5）、（75.4±22.4）、（64.8±25.6）分。各治疗后与治疗前比较差异有统计学意义。（3）对181膝进行1年随访的长期疗效评估，优70例，良54例，可34例，差23例。2年随访者，优40例，良54例，可53例，差34例。膝关节功能随时间推移变差。治疗后2年，轻度、中度、重度膝关节的有效率分别为86.89%（53/61）、79.
