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Choroidal melanocytes - a model for studying the aging process in nonreplicative differentiated cells.

作者信息

Hu F, Mah K

出版信息

Mech Ageing Dev. 1979 Nov;11(4):227-35. doi: 10.1016/0047-6374(79)90002-2.

DOI:10.1016/0047-6374(79)90002-2
PMID:118309
Abstract

Choroidal melanocytes differentiate and cease to divide early in postnatal life. They have characteristic organelles, the melanosomes, which are formed from tyrosine in a reaction catalyzed by tyrosinase. As animals become old, enzyme activity declines and the melanosomes show changes that are quantitatively and qualitatively correlated to the animal's increasing age.

摘要

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