Ball J H, Lowrie E G, Hampers C L, Merrill J P
Clin Nephrol. 1975;4(3):91-8.
30 patients undergoing regular, three times weekly hemodialysis were treated with large doses of intramuscular testosterone with evaluation of hematopoiesis before and after treatment. A control group of 30 patients not using the drug was evaluated in similar fashion. The presence or absence of native kidneys was the most important factor determining hematocrit level and transfusion requirements in these patients, whether treated with testosterone or not. The mean hematocrit was lower and the transfusion requirements were higher in bilaterally nephrectomized patients. A significant increase in hematocrit occurred in testosterone treated nephric patients, but untreated nephric patients also had a significant rise. Important adverse side effects occurred with testosterone. Anephric patients did not increase hematocrit levels with or without testosterone.
30名接受每周三次常规血液透析的患者接受了大剂量肌肉注射睾酮治疗，并在治疗前后对造血功能进行了评估。以类似方式对30名未使用该药物的患者组成的对照组进行了评估。无论是否接受睾酮治疗，是否有天然肾脏是决定这些患者血细胞比容水平和输血需求的最重要因素。双侧肾切除患者的平均血细胞比容较低，输血需求较高。接受睾酮治疗的有肾患者血细胞比容显著增加，但未治疗的有肾患者也有显著升高。睾酮出现了重要的不良副作用。无肾患者无论是否使用睾酮，血细胞比容水平均未升高。
